ID 110855
Author
Kanamoto, Mami Department of Digestive and Pediatric Surgery, nstitute of Health Biosciences The University of Tokushima Graduate School KAKEN Search Researchers
Yoshizumi, Tomoharu Department of Digestive and Pediatric Surgery, nstitute of Health Biosciences The University of Tokushima Graduate School
Ikegami, Toru Department of Digestive and Pediatric Surgery, nstitute of Health Biosciences The University of Tokushima Graduate School
Imura, Satoru Department of Digestive and Pediatric Surgery, nstitute of Health Biosciences The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Morine, Yuji Department of Digestive and Pediatric Surgery, nstitute of Health Biosciences The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ikemoto, Tetsuya Department of Digestive and Pediatric Surgery, nstitute of Health Biosciences The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sano, Nobuya Department of Pathology, Institute of Health Biosciences The University of Tokushima Graduate School
Shimada, Mitsuo Department of Digestive and Pediatric Surgery, nstitute of Health Biosciences The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
a rare tumor of the liver
cholangiocellular carcinoma
cholangiolocellular carcinoma
hepatic stem cell
hepatocellular carcinoma
Content Type
Journal Article
Description
Cholangiolocellular carcinoma (CLC) is an extremely rare malignant liver tumor which was first defined by Steiner, et al . in 1957 (1). CLC is thought to be derived from Hering’s canal because tumor glands of CLC are morphologically similar to cholangioles. Recently, Theise, et al . reported that Hering’s canal might be composed of hepatic stem cells (3). In addition, CLC sometimes contains a hepatocellular carcinoma (HCC) or cholangiocellular carcinoma (CCC) component within the tumor. Those findings suggest that CLC might originate from hepatic stem cells. On the other hand, because of its low frequency, clinicopatholigical features of CLC have not been fully clarified yet. We herein report a case of a 71-year old man with CLC. Based on preoperative imagings, the hepatic tumor was diagnosed as HCC, and he underwent a partial hepatectomy. The tumor contained both a HCC and CCC-like area. In immunohistochemistry, cytokeratin (CK) 7, CK20, CAM5.2 was positive, and CK19 was negative, therefore the tumor was diagnosed as CLC. The diagnostic criteria have not been described clearly, so CLC is difficult to diagnose preoperatively. Further studies are needed to clarify the clinical and clinicopatholigical features of CLC.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Publisher
The University of Tokushima Faculty of Medicine
Volume
55
Issue
1-2
Start Page
161
End Page
165
Sort Key
161
Published Date
2008-02
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences