ID 110858
Author
Sato, Kazusa Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Arai, Hidekazu Laboratory of Clinical Nutrition Management, Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences, the University of Shizuoka
Miyazawa, Yui Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Fukaya, Makiko Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Uebanso, Takashi Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Koganei, Megumi Division of Research and Development, Food Science Institute, Meiji Dairies Corporation
Sasaki, Hajime Division of Research and Development, Food Science Institute, Meiji Dairies Corporation
Sato, Tadatoshi Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Yamamoto, Hironori Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Taketani, Yutaka Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Takeda, Eiji Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Zucker fatty (fa/fa) rats
isomaltulose (palatinose)
sucrose
oleic acid
linoleic acid
pancreatic islet
Content Type
Journal Article
Description
We showed previously that 8-wk consumption of a diet containing palatinose (P, a slowly-absorbed sucrose analogue) and oleic acid (O) ameliorates but a diet containing sucrose (S) and linoleic acid (L) aggravates metabolic abnormalities in Zucker fatty (fa/fa) rats. In this study, we aimed to identify early changes in metabolism in rats induced by certain combinations of carbohydrates and fatty acids. Specifically, male Zucker fatty rats were fed an isocaloric diet containing various combinations of carbohydrates (P S) and fatty acids (O L). After 4 wk, no significant differences in bodyweight, visceral fat mass, plasma parameters (glucose, insulin, lipids, and adipokines), hepatic adiposity and gene expression, and adipose inflammation were observed between dietary groups. In contrast, pancreatic islets of palatinose-fed (PO and PL) rats were smaller and less fibrotic than sucrose-fed (SO and SL) rats. The abnormal_-cell distribution and sporadic staining of active caspase-3 common to islets of linoleic-acid-fed rats were not observed in oleic-acid-fed (PO and SO) rats. Accordingly, progressive_-cell loss was seen in SL rats, but not in PO rats. These findings suggest that pancreatic islets may be initial sites that translate the effects of different combinations of dietary carbohydrates and fats into metabolic changes.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
55
Issue
3-4
Start Page
183
End Page
195
Sort Key
183
Published Date
2008-08
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences