ID 110876
Author
Takayama, Tetsuji Department of Gastroenterology and Oncology, Institutes of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Goji, Takahiro Department of Gastroenterology and Oncology, Institutes of Health Bioscience, the University of Tokushima Graduate School KAKEN Search Researchers
Taniguchi, Tatsuya Department of Gastroenterology and Oncology, Institutes of Health Bioscience, the University of Tokushima Graduate School
Inoue, Atsushi Department of Gastroenterology and Oncology, Institutes of Health Bioscience, the University of Tokushima Graduate School
Keywords
colorectal cancer
chemoprevention
aberrant crypt foci
Content Type
Journal Article
Description
Colorectal cancer is a leading cause of cancer-related mortality worldwide. Therefore, an appropriate prevention strategy should be urgently established. Chemoprevention involves the use of oral agents to suppress the development of cancer. Recent progress in the molecular analysis of colorectal cancer has revealed many candidate molecules for chemoprevention. Many new agents targeting these molecules have also been developed. These agents are largely classified into three categories : 1) Signal transduction modulators including epidermal growth factor (EGF) receptor inhibitors, anti-vascular endothelial growth factor (VEGF) antibodies, and inhibitors of oncogene products. 2) Epigenetic modulators including peroxisome proliferative activated receptor (PPAR)-γ agonists, estrogen receptor (ER)-β , and histone deacetylase inhibitors. 3) Anti-inflammatory modulators including cyclooxygenase (COX)-2, EP 1-4, and NF-kB. Of these agents, some actually proceeded to human clinical trials, and have been shown to be active chemopreventive agents.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
56
Issue
1-2
Start Page
1
End Page
5
Sort Key
1
Published Date
2009-02
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital