ID 110877
Author
Muniandy, Sekaran Department of Molecular Medicine, Faculty of Medicine, University of Malaya
Qvist, Rajes Department of Medicine, Faculty of Medicine, University of Malaya
Yan, Gracie Ong Siok Department of Anaesthesiology, Faculty of Medicine, University of Malaya
Bee, Chook Jack Department of Medicine, Faculty of Medicine, University of Malaya
Chu, Yiaw Koon Deparment of Pathology, Faculty of Medicine, University of Malaya
Rayappan, Arokiasamy Vinsent Department of Medicine, Faculty of Medicine, University of Malaya
Keywords
hyperglycaemia
sepsis
insulin
glutamine
Content Type
Journal Article
Description
Hyperglycemia and insulin resistance are common in many critically ill patients. Hyperglycemia increases the production of reactive oxygen species in cells, stimulates the production of the potent proinflammatory cytokines IL-8 and TNF-alpha, and enhances the expression of haem oxygenase-1, an inducible stress protein. It has been shown that administration of insulin and the semi-essential amino acid glutamine have been beneficial to the septic patient. The aim of our study is to test whether these two molecules, glutamine and insulin used in combination attenuate the proinflammatory responses in endothelial cells which have been triggered by hyperglycaemia. Our results demonstrate that a combination of insulin and glutamine are significantly more effective in reducing the expression of IL-8, TNF-alpha and HO-1 than insulin or glutamine alone.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
56
Issue
1-2
Start Page
6
End Page
10
Sort Key
6
Published Date
2009-02
FullText File
language
eng
TextVersion
Publisher