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ID 110920
Title Alternative
Foxn1−β5t転写制御軸は胸腺でのCD8陽性T細胞生成を制御する
Author
Uddin, Md.Myn University of Tokushima
Motosugi, Ryo University of Tokyo
Nakayama, Tomomi University of Tokyo
Sakata, Mie University of Tokushima
Hamazaki, Jun University of Tokyo
Nishito, Yasumasa Tokyo Metropolitan Institute of Medical Science
Rode, Immanuel German Cancer Research Center
Tanaka, Keiji Tokyo Metropolitan Institute of Medical Science
Murata, Shigeo University of Tokyo
Keywords
胸腺
胸腺上皮細胞
CD8陽性T細胞
胸腺プロテアソーム
転写制御
Content Type
Thesis or Dissertation
Description
The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T-cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of β5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8+ T cells. A point mutation in this genome element results in a defect in β5t expression and CD8+ T-cell production in mice. The results reveal a Foxn1-β5t transcriptional axis that governs CD8+ T-cell production in the thymus.
Journal Title
Nature Communications
ISSN
20411723
NCID
AA12645905
Publisher
Springer nature
Volume
8
Start Page
14419
Published Date
2017-02-08
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Muhammad Myn Uddinの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
© The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3099号
Diploma Number
甲医第1343号
Granted Date
2017-09-28
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Institute of Advanced Medical Sciences