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ID 110928
Title Alternative
心エコー図検査で計測した心外膜下脂肪厚は誘発試験中の症候性冠攣縮と関連する
Author
Nishio, Susumu Tokushima University
Hirata, Yukina Tokushima University
Shimabukuro, Michio Fukushima Medical University KAKEN Search Researchers
Keywords
Echocardiography
Epicardial adipose tissue
Vasospasm in patients with angina
Anterior interventricular groove
Content Type
Thesis or Dissertation
Description
Background: Epicardial adipose tissue (EAT) is the ectopic visceral fat surrounding the heart, which plays an important role in atherosclerosis of the coronary arteries via endothelial damage. Several studies have also suggested that vasospasmwith angina (VSA) causes endothelial dysfunction in the coronary arteries. The aimof this study was to evaluate the thickness of EAT in the anterior interventricular groove (EAT-AIG) using echocardiography in patients who had no obstructive coronary artery disease and were suspected of having VSA.

Methods: Sixty-five patients who underwent intracoronary acetylcholine provocation testing for clinical indications were prospectively enrolled. VSA was diagnosed by coronary artery stenosis increase of >90% and the presentation of chest pain with ischemic changes on electrocardiography.

Results: Subjects were divided into two groups, with and without significant coronary spasm (VSA group, 30 patients; non-VSA group, 35 patients), consistent with acetylcholine provocation testing. EAT-AIG thickness was significantly greater in the VSA group than in the non-VSA group (8.2±2.7 vs 6.1±2.5 mm, P = .002). By receiver operating characteristic analysis, EAT-AIG thickness had a high C statistic (area under the curve = 0.81, P < .001) after adjustment for conventional risk factors (smoking, diabetes mellitus, and dyslipidemia). EAT-AIG thickness had incremental diagnostic value over other conventional risk factors (area under the curve = 0.81 vs 0.64, P for comparison = .020).

Conclusions: EAT-AIG thickness, which is noninvasively and easily measured using transthoracic echocardiography, can be one of multiple clinical variables associated with VSA.
Journal Title
Journal of the American Society of Echocardiography
ISSN
08947317
NCID
AA10709494
Publisher
The American Society of Echocardiography|Elsevier
Volume
30
Issue
10
Start Page
1021
End Page
1027.e1
Published Date
2017-08-23
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Susumu Nishioの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3104号
Diploma Number
甲医第1348号
Granted Date
2017-09-28
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences