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ID 110960
Title Alternative
大腸癌における抗EGFR抗体薬治療後のEGFR Downregulationは抗腫瘍効果を予測する
EGFR Down-regulation Predicts anti-EGFR Response
Author
Fujimoto, Shota Tokushima University
Tsuji, Yasushi Tonan Hospital
Keywords
Colorectal cancer
EGFR
cetuximab
internalization
degradation
Content Type
Thesis or Dissertation
Description
ABC, antibody-binding capacity; ADCC, antibody-dependent cellular cytotoxicity; ATCC, American Type Culture Collection; BSA, bovine serum albumin; CR, complete response; CRC, colorectal cancer; CT, computed tomography; ECACC, European Collection of Authenticated Cell Cultures; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ETS, early tumor shrinkage; FBS, fetal bovine serum; FISH, fluorescent in situ hybridization; HRP, horseradish peroxidase; HSRRB, Health Science Research Resources Bank; IHC, immunohistochemistry; MesNa, Mercaptoethanesulfonic acid sodium; mCRC, metastatic colorectal cancer; mAb, monoclonal antibody; mAbs, monoclonal antibodies; PARP, poly (ADP-ribose) polymerase; PBS, phosphate buffered saline; PD, progressive disease; p-ERK, phosphorylated ERK; PNA-LNA, peptide nucleic acid-locked nucleic acid; PR, partial response; PVDF, polyvinylidene difluoride; RECIST, Response Evaluation Criteria in Solid Tumors; RIKEN BRC, RIKEN BioResource Center; SD, stable disease; SDS, sodium dodecyl sulfate; SDS-PAGE, SDS-polyamide gel electrophoresis; TBS-T, Tris-buffered saline with 0.1% Tween; TGF-α, transforming growth factor-α.
Journal Title
Molecular Cancer Research
ISSN
15417786
15573125
NCID
AA11795083
AA12004955
Publisher
American Association for Cancer Research
Volume
15
Issue
10
Start Page
1445
End Page
1454
Published Date
2017-07-11
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yasuyuki Okadaの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3116号
Diploma Number
甲医第1351号
Granted Date
2017-10-26
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital