ID 111066
Title Alternative
Regulation of Cell Cycle by Ubiquitin-mediated Proteolysis and Carcinogenesis Induced by Its Dysregulation
Author
Keywords
細胞周期
ユビキチン分解
プロテアソーム
Content Type
Journal Article
Description
In the process of carcinogenesis, abnormal regulation of cell cycle regulators is essential. Cell cycle is driven by the activity of Cyclin/Cyclin-dependent kinase (Cdk) complex. The activity of Cyclin/Cdk1 is regulated by the ubiquitin-proteasome pathway via controlling protein level of Cyclins. In addition to Cyclins, the protein level of various cell cycle regulators is strictly and precisely regulated by the ubiquitin-proteasome pathway. In particular, SCF (Skp1-Cullin-F-box) and anaphasepromoting complex/cyclosome (APC/C) ubiquitin ligase complex are involved in ubiquitylation of cell cycle regulators. It recently has been shown that overexpression of oncogenic cell cycle regulators and reduced expression of tumor suppressive cell cycle regulators are caused by abnormal regulation of ubiquitin-mediated proteolysis in cancer. In this review, we introduce abnormal regulation of cell cycle regulators in cancer.
Journal Title
Journal of Oral Health and Biosciences
ISSN
21896682
Publisher
四国歯学会
Volume
30
Issue
1
Start Page
33
End Page
39
Sort Key
33
Published Date
2017-06-30
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences