ID 111120
Author
Matsuura, Sayaka Tokushima University
Shirai, Yumiko Iga City General Hospital
Kubo, Miyu Tokushima University
Nayama, Chisako Tokushima University
Okitsu, Masami Tokushima University
Oiwa, Yuu Tokushima University
Murata, Tomohiro Mie University|Iga City General Hospital
Ishikawa, Eiji Mie University|Iga City General Hospital
Miki, Chikao Iga City General Hospital
Keywords
bioelectrical impedance analysis
nutrition
prealbumin
protein-energy wasting
Content Type
Journal Article
Description
Serum transthyretin (TTR), also known as prealbumin, is a reliable nutritional indicator and an independent prognostic factor for maintenance hemodialysis patients. However, we recently reported that serum TTR levels did not affect protein−energy wasting (PEW). In this study, we investigated factors affecting serum TTR levels in 60 maintenance hemodialysis patients. The patients were divided into High-TTR and Low-TTR groups according to the median serum TTR level. Albumin levels were significantly higher and C-reactive protein (CRP) levels were significantly lower in the High-TTR group than in the Low-TTR group. Although body fat mass was significantly higher in the High-TTR group than in the Low-TTR group, no significant difference in body fat ratio were observed. These findings suggest that body fat mass is related to serum TTR levels, apart from factors such as albumin and CRP levels, which showed correlations with serum TTR levels. Because body fat mass is related to better survival in maintenance hemodialysis patients, it may contribute to the prognostic value of serum TTR levels. In addition, in such patients, it may be important to evaluate body fatmass rather than body fat ratio and to maintain the minimum necessary body fat mass.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
64
Issue
3-4
Start Page
222
End Page
227
Sort Key
222
Published Date
2017-08
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences