ID 111139
Author
Tsunezuka, Yoshio Ishikawa Prefectural Central Hospital
Tanaka, Nobuyoshi Ishikawa Prefectural Central Hospital
Fujimori, Hideki Ishikawa Prefectural Central Hospital
Togashi, Yuki Japanese Foundation for Cancer Research
Baba, Satoko Japanese Foundation for Cancer Research
Takeuchi, Kengo Japanese Foundation for Cancer Research
Katayanagi, Kazuyoshi Ishikawa Prefectural Central Hospital
Kurumaya, Hiroshi Ishikawa Prefectural Central Hospital
Kitade, Hironori Houju Memorial Hospital
Atagi, Shinji Kinki-Chuo Chest Medical Center
Yano, Seiji Houju Memorial Hospital|Kanazawa University
Keywords
EGFR mutation
EML4-ALK
double cancers
alectinib
Content Type
Journal Article
Description
A 36-year-old male was found two nodules in the right lower lobe of the lung. After the surgical resection, both lesions were diagnosed as invasive adenocarcinomas. One lesion was primarily lepidic growth component with EGFR-L858R mutation, and the other was micropapillary component with ALK translocation accompanying mediastinal lymphnode metastases. While he experienced disease recurrence, the disease was controlled by an ALK inhibitor, given based on the findings of surgical specimens. This is the first case who had two simultaneous lung cancers with EGFR mutation and ALK translocation in each respective lesion, and was successfully treated with ALK inhibitor at the post-surgical recurrence.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
64
Issue
3-4
Start Page
305
End Page
307
Sort Key
305
Published Date
2017-08
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher