ID 111164
Author
Takayama, Mio Fukuoka University
Kashiwagi, Masayuki Fukuoka University
Matsusue, Aya Fukuoka University
Waters, Brian Fukuoka University
Hara, Kenji Fukuoka University
Ikematsu, Natsuki Fukuoka University
Kubo, Shin-ichi Fukuoka University
Keywords
dementia
senile plaque
neurofibrillary tangle
pathological diagnosis
quantification of neuropathological findings
forensic autopsy
Content Type
Journal Article
Description
The aim of the present study was to quantify neuropathological findings using image analysis software for the diagnosis of dementia in deceased who underwent forensic autopsy. Of the autopsies performed within 48 hours of death and excluding those of patients with head injury, thermal injury, heat stroke, or intracranial lesions, 8 were of autopsy cases clinically diagnosed with dementia and thus included in the dementia group (D). The non-dementia group (non-D) consisted of 6 deceased without dementia. To compare the D and non-D groups, 6 regions and 7 types of pathological findings were observed semi-quantitatively using 4 conventional stainings. Quantitative analysis of collected image data was performed using image analysis software. Semiquantitative analysis of senile plaques and neurofibrillary tangles was performed with Bielschowsky-Hirano’s silver staining image data. An easy, simple, and effective quantification method of the pathological findings was achieved. However, no significant differences were observed between the two groups, and diagnosis of dementia by the quantification of pathological findings was not successful. Diagnosis of dementia using image data may be possible in future studies with an increased number of autopsies, and by utilizing staining techniques with higher specificity and sensitivity, such as immunohistochemical staining.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
63
Issue
1-2
Start Page
114
End Page
118
Sort Key
114
Published Date
2016-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher