ID 111175
Author
Miyoshi, Takanori Tokushima Municipal Hospital
Mori, Riho Tokushima Municipal Hospital
Amano, Sachiko Tokushima Municipal Hospital
Sumitomo, Hiroyuki Tokushima Municipal Hospital
Aoyama, Mariko Tokushima Municipal Hospital
Hino, Naoki Tokushima Municipal Hospital
Wada, Daisuke Takamatsu Municipal Hospital
Keywords
Gastrointestinal stromal tumors
Synchronous lung cancer
Molecular targeting drugs
Content Type
Journal Article
Description
The synchronous existence of lung cancer and gastrointestinal stromal tumors (GIST) is considered to be extremely rare. To the best of our knowledge, this is the first report about the treatment of lung cancer and GIST with two kinds of molecular targeting drugs. An 83-year-old woman with a rectal GIST, which carried a c-kit mutation, and pulmonary adenocarcinoma, which exhibited an epidermal growth factor receptor (EGFR) mutation, was treated alternately with imatinib and erlotinib. Good control over both diseases was achieved for two years. The present case is not only of interest due to the rare co-occurrence of GIST and lung cancer, but also because it involved two tumors carrying different gene mutations, and both tumors were brought under control using different molecular targeting drugs.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
63
Issue
1-2
Start Page
144
End Page
148
Sort Key
144
Published Date
2016-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences