ID 111250
Author
Katai, Kanako Doshisha Women’s College of Liberal Arts
Iwamoto, Aya Doshisha Women’s College of Liberal Arts
Kimura, Yuka Doshisha Women’s College of Liberal Arts
Oshima, Yuki Doshisha Women’s College of Liberal Arts
Arioka, Saori Doshisha Women’s College of Liberal Arts
Morimi, Yuki Doshisha Women’s College of Liberal Arts
Omuro, Ayaka Doshisha Women’s College of Liberal Arts
Nakasa, Teruko Doshisha Women’s College of Liberal Arts
Keywords
inorganic phosphate
hyperphosphatemia
seaweed
fucoidan
alginic acid
Content Type
Journal Article
Description
In chronic renal failure, inorganic phosphate (Pi) retention speeds up the progression to end-stage renal disease. The current therapy for hyperphosphatemia in patients with chronic renal failure consists of dietary Pi restriction combined with administration of Pi binders, but each therapy has practical problems. Thus, the discovery of foods or nutrients that inhibit Pi absorption may be useful for the treatment of hyperphosphatemia. In the present study, we investigated whether wakame (Undaria pinnatifida) is a useful food for the prevention of hyperphosphatemia in a rat model of renal failure. Feeding a diet containing 5% wakame significantly decreased plasma and urinary Pi levels and increased the amount of fecal Pi. In addition, wakame significantly reduced plasma blood urea nitrogen and plasma Pi levels in 5/6 nephrectomized rats fed a high-Pi diet. Biochemical analyses showed that the reduction of intestinal Pi absorption is the main reason for the decrease in plasma Pi levels in rats fed a diet containing wakame. In addition, feeding alginic acid and fucoidan, major components of wakame fiber, was effective in reducing plasma Pi levels in normal rats. Finally, we concluded that wakame may be a useful food for the prevention of hyperphosphatemia in rodents.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
62
Issue
1-2
Start Page
68
End Page
74
Sort Key
68
Published Date
2015-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher