ID 111295
Author
Kishi, Kazuhiro Kagawa Prefectural Shirotori Hospital
Fujisawa, Akihiko Kagawa Prefectural Shirotori Hospital
Horikita, Minoru Kagawa Prefectural Shirotori Hospital
Nakai, Yoshihiro Kagawa Prefectural Shirotori Hospital
Ooshimo, Kazushi Kagawa Prefectural Shirotori Hospital
Kishi, Fumiko Tokushima University
Kimura, Masako Tokushima University
Lin, Chun-che Kagawa University
Keywords
NET
neuroendocrine carcinoma
gastric carcinoma
CD56
synaptophysin
Content Type
Journal Article
Description
Gastric neuroendocrine tumor (NET) is sometimes found as a submucosal tumor on upper gastrointestinal endoscopy. Gastric NET with malignant profile and neuroendocrine carcinoma (NEC) show various forms which are difficult to distinguish from gastric cancer and other disease. We report a case of a cauliflower-shaped NET of the stomach. A 61-year-old man was referred to our hospital with a complaint of abdominal fullness. Upper gastrointestinal endoscopic examination revealed an unusual, whitish cauliflower-shaped tumor that belongs to Borrmann type I on the lesser curvature of the gastric antrum. Histological examination of the biopsy specimen revealed NET G2, because the tumor cells were CD56- and synaptophysin-positive by immunohistochemical analysis. A distal gastrectomy with D2 lymphadenectomy was performed. A recurrence in the liver was revealed by follow up computed tomography after 11 months from operation. Combined chemotherapy with irinotecan (CPT-11) plus cisplatin (CDDP) was treated. The patient achieved a partial response, but he died after 31 months from gastrectomy. There is no independent, large-scaled prospective study and no standard treatment for gastric NETs with distant metastases. Our case is reported with a literature review of the treatment of metastatic gastric NET G2.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
62
Issue
3-4
Start Page
251
End Page
257
Sort Key
251
Published Date
2015-08
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences