ID 111328
Author
Catalán, Marcelo A University of Rochester Medical Center
Nakamoto, Tetsuji Kyushu Dental College
Melvin, James E University of Rochester Medical Center
Keywords
fluid secretion
NaCl absorption
salivary glands
Content Type
Journal Article
Description
Fluid secretion by exocrine glands requires the coordinated activity of multiple water and ion transporter and channel proteins. The molecular cloning of many of the transporter molecules involved in fluid secretion has yielded a better understanding of the fluid secretion process. Mouse salivary glands are easily accessible model systems for the study of exocrine gland secretion at the cellular and organ level. Indeed, the characterization of mice with null mutations in many of the water and ion transporter and channel genes has demonstrated the physiological roles of individual proteins. This overview will focus on recent developments in determining the molecular identification of the proteins that are involved in the fluid secretion process.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
56
Issue
Supplement
Start Page
192
End Page
196
Sort Key
192
Published Date
2009-12
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher