ID 111363
Author
Ko, Shigeru BH Nagoya University
Mizuno, Nobumasa Aichi Cancer Center Hospital
Yatabe, Yasushi Aichi Cancer Center Hospital
Yoshikawa, Toshiyuki Nagoya University
Ishiguro, Hiroshi Nagoya University
Yamamoto, Akiko Nagoya University
Azuma, Sakiko Nagoya University
Naruse, Satoru Nagoya University
Yamao, Kenji Aichi Cancer Center Hospital
Muallem, Shmuel UT Southwestern Medical Center
Goto, Hidemi Nagoya University
Keywords
Aquaporin1
autoimmune pancreatitis
immunolocalization
pancreatic exocrine function
secretin test
Content Type
Journal Article
Description
Chronic pancreatitis with all kinds of etiologies is characterized by pancreatic exocrine dysfunction especially impaired fluid secretion from pancreatic ducts. However, the molecular mechanism of this impaired fluid secretion in chronic pancreatitis is largely unknown. Aquaporin water channels are intrinsic membrane proteins expressed most of the cell types which have high osmotic water permeability. Among them aquaporin 1 (AQP1) is a predominant water channel expressed in the plasma membranes of human pancreatic ducts. Exocrine function test revealed that fluid secretion was severely impaired in AIP. immunohistochemical analysis revealed that AQP1 is localized mainly in the apical and lateral membranes of small pancreatic ducts in control subjects. AQP1 expression was significantly increased in plasma membranes of pancreatic ducts in AIP. Upregulation of AQP1 expression seen in pancreatic ducts of patient with AIP may be caused by the reduced fluid secretion from the pancreas as compensation. Further study would be required to elucidate the precise molecular mechanism for the role of AQP1 in pancreatic fluid secretion from the pancreas in diseases characterized by the impaired ductal fluid secretion such as cystic fibrosis.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
56
Issue
Supplement
Start Page
318
End Page
321
Sort Key
318
Published Date
2009-12
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher