ID 111388
Author
Niimura, Takahiro Tokushima University
Imai, Toru Nihon University
Ito, Tsuyoshi Okayama University
Sagara, Hidenori Matsuyama University
Hichiya, Hiroyuki Godai Pharmacy
Esumi, Satoru Okayama University
Koyama, Toshihiro Okayama University
Amano, Manabu Hyogo University of Health Sciences
Kurata, Naomi Showa University
Kitamura, Yoshihisa Okayama University
Nakura, Hironori Okayama University
Sendo, Toshiaki Okayama University
Keywords
Emergency and critical care medical center
Kampo product
simple suspension method
tube administration
Content Type
Journal Article
Description
In emergency and critical care medical centers, tube administration is employed for patients who have difficulty swallowing oral drugs owing to decreased consciousness or mechanical ventilation. However, tube clogging due to drug injection is a concern. We compared the crushing method with the simple suspension method for the passage of amlodipine, an antihypertensive drug, in combination with rikkunshito, which has been used to treat upper gastrointestinal disorders such as functional dyspepsia and gastroesophageal reflux in emergency and critical care medical centers, to ascertain the effect of Kampo products on the passage of other drugs during tube administration. When the crushing method was employed, poorly water-soluble solid products were formed, while a uniformly dispersed suspension was obtained using the simple suspension method. In addition, the passage rate of amlodipine through the tube was 64% and 93% in the crushing and simple suspension methods, respectively, thereby indicating that the simple suspension method provided more favorable than the crushing method. The results of this study suggested that the passage rate of amlodipine for patients who received Kampo products concurrently was higher when the simple suspension method was used, and an appropriate drug amount might well be able to administered to patients using this method.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
65
Issue
1-2
Start Page
32
End Page
36
Sort Key
32
Published Date
2018-02
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital