ID 111409
Author
Kawamura, Hiromi University of Hyogo
Tanaka, Sarasa University of Hyogo
Uenami, Yuri University of Hyogo
Tani, Mariko University of Hyogo
Ishitani, Midori University of Hyogo
Morii, Saeko University of Hyogo
Sakaue, Motoyoshi University of Hyogo
Ito, Mikiko University of Hyogo
Keywords
Refeeding syndrome
hypophosphatemia
total parenteral nutrition
animal model
insulin
Content Type
Journal Article
Description
Refeeding syndrome (RFS) is characterized by the metabolic and clinical changes that occur following aggressive nutritional supplementation in malnourished patients. Hypophosphatemia is the hallmark of RFS and is key to its prevention and treatment in clinical practice. However, the mechanism of hypophosphatemia during RFS is unclear because of the lack of an animal model. In this study,we developed a rat RFS model as a first step to clarifying the molecular mechanism. After establishing the parenteral route, rats were fasted for 5 days and refeeding was started using total parenteral nutrition. The animals were infused with a high calorie solution with or without insulin administration. Results showed that plasma phosphate levels did not decrease in rats infused with the high calorie solution alone ; in contrast, a 20% reduction compared to baseline was observed in rats administered insulin. In addition, rats infused with the high calorie solution containing added phosphate did not present with hypophosphatemia. Thus, we developed a rat RFS model with hypophosphatemia by tube feeding and insulin administration, and demonstrated the importance of phosphate in preventing refeeding hypophosphatemia.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
65
Issue
1-2
Start Page
50
End Page
55
Sort Key
50
Published Date
2018-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher