ID 111412
Author
Zhang, Shukun Weihai Municipal Hospital|Qinghai Provincial People’s Hospital
Liu, Juanli Qinghai Provincial People’s Hospital
Jiang, Dongmei Qinghai Provincial People’s Hospital
Wuren, Tana Qinghai University
Ma, Siqing Qinghai Provincial People’s Hospital
Du, Yansheng Indiana University
Yi, Xin Indiana University
Wu, Shizheng Qinghai Provincial People’s Hospital
Keywords
Vascular endothelial growth factor
Soluble VEGF receptor
High altitude pulmonary edema
Content Type
Journal Article
Description
Hypoxia-induced plasma levels of VEGF and sFlt-1 are responsible for increased vascular permeability occurred in both brain and pulmonary edema. Currently, it remains unclear the exact roles of VEGF and sFlt-1 in High Altitude Pulmonary Edema (HAPE) pathogenesis. In this study, plasma levels of VEGF and sFlt-1 from 10 HAPE and 10 non-HAPE subjects were measured and compared. The results showed that plasma levels of both VEGF and sFlt-1 in HAPE patients were significantly increased as compared to the non-HAPE group. Interestingly, increased plasma levels of these two protein factors were markedly reduced after treatments. As compared to VEGF, sFlt-1 was much more affected by hypoxia and treatments, suggesting this factor was a key factor contributed to HAPE pathogenesis. Importantly, the ratio of sFlt-1 and VEGF in group of either non-HAPE or HAPE after recovery was significantly lower than the ratio in HAPE patients prior to treatments. Our findings suggested that sFlt-1 was a key factor that involved in HAPE pathogenesis and the sFlt-1/VEGF ratio could be used as a sensitive diagnostic marker for HAPE.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
65
Issue
1-2
Start Page
64
End Page
68
Sort Key
64
Published Date
2018-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher