ID 111446
Author
Akamatsu, Yukinobu Tottori University
Morishita, Shota Tottori University
Chikumi, Hiroki Tottori University
Okamoto, Ryo Tottori University
Okada, Kensaku Tottori University
Kitaura, Tsuyoshi Tottori University
Miyake, Naomi Tottori University
Yamaguchi, Kosuke Tottori University
Nakamoto, Masaki Tottori University
Shimohiro, Hisashi Tottori University
Takata, Miyako Tottori University
Yamasaki, Akira Tottori University
Burioka, Naoto Tottori University
Shimizu, Eiji Tottori University
Keywords
C. Diff Quik Chek Complete assay
Clostridium difficile (C. difficile)
C. difficile-associated diarrhea (CDAD)
GDH positive/toxin negative
Content Type
Journal Article
Description
Clostridium difficile (C. difficile)-associated diarrhea (CDAD) is a challenging nosocomial infectious disease. C. DIFF Quik Chek Complete assay is widely used to detect glutamate dehydrogenase (GDH) antigen and toxin A/B of C. difficile simultaneously. However, the interpretation of GDH positive/toxin negative results is problematic.We performed a retrospective study of patients with GDH positive/toxin negative results to determine the probability of detecting toxigenic C. difficile and its risk factors. Between April 2012 and March 2017, we investigated cultures of fecal specimens followed by toxin detection tests. The clinical histories of patients with and without toxigenic C. difficile were compared using univariate- and multivariate-analyses. In total, 2675 patients were examined using C. Diff Quik Chek Complete assay. Among 356 GDH positive/toxin negative patients, cultures were performed in 220 cases and toxigenic C. difficile was recovered from 139 (63.2%) specimens. Patients with toxigenic C. difficile had significantly lower body mass index than those without. Over half the GDH positive/toxin negative patients were infected with toxigenic C. difficile. Lower BMI was a CDAD risk factor in this patient population. These data can be utilized to initiate isolation and clinical interventions before confirmatory test results are available.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
65
Issue
1-2
Start Page
131
End Page
135
Sort Key
131
Published Date
2018-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher