Kim, Dusik University of Manchester
Steward, Martin C University of Manchester
The secretory epithelia of the pancreatic duct and airway share the ability to generate HCO3--rich fluids. They both express CFTR (cystic fibrosis transmembrane conductance regulator) at the apical membrane and both are adversely affected by cystic fibrosis. CFTR is predominantly a Cl- channel, and it is widely believed that HCO3- secretion in the pancreatic duct is mediated mainly by a Cl-/HCO3- exchanger at the apical membrane. Studies on airway epithelia, however, have suggested that CFTR, despite its low permeability to HCO3-, may nonetheless be directly responsible for HCO3- secretion across the apical membrane. This article reviews recent work that has re-examined both of these hypotheses.
The Journal of Medical Investigation
Faculty of Medicine Tokushima University
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jmi_56_suppl_336.pdf 299 KB