ID 111457
Author
Kim, Dusik University of Manchester
Steward, Martin C University of Manchester
Keywords
epithelial transport
exocrine secretion
exocrine glands
cystic fibrosis
Content Type
Journal Article
Description
The secretory epithelia of the pancreatic duct and airway share the ability to generate HCO3--rich fluids. They both express CFTR (cystic fibrosis transmembrane conductance regulator) at the apical membrane and both are adversely affected by cystic fibrosis. CFTR is predominantly a Cl- channel, and it is widely believed that HCO3- secretion in the pancreatic duct is mediated mainly by a Cl-/HCO3- exchanger at the apical membrane. Studies on airway epithelia, however, have suggested that CFTR, despite its low permeability to HCO3-, may nonetheless be directly responsible for HCO3- secretion across the apical membrane. This article reviews recent work that has re-examined both of these hypotheses.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
56
Issue
Supplement
Start Page
336
End Page
342
Sort Key
336
Published Date
2009-12
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher