ID 111467
Author
Wang, Di The University of Tokushima
Iwata, Fusako Otsuka Pharmaceutical Co.
Muraguchi, Masahiro Otsuka Pharmaceutical Co.
Ooga, Keiko Otsuka Pharmaceutical Co.
Ohmoto, Yasukazu Otsuka Pharmaceutical Co.
Takai, Masaaki Otsuka Pharmaceutical Co.
Mori, Toyoki Otsuka Pharmaceutical Co.
Ishikawa, Yasuko The University of Tokushima KAKEN Search Researchers
Keywords
salivary composition
water channel
aquaporin-5
lipid raft
salivary flow rate
Content Type
Journal Article
Description
Saliva samples are useful for noninvasive diagnosis of oral and systemic diseases. The water channel protein aquaporin-5 (AQP5) is released into human saliva. Salivary AQP5 levels show a diurnal variation with the secretion of high levels during the waking hours. An age-related decrease in salivary AQP5 levels parallels a decrease in the volume of saliva. Cevimeline, a muscarinic acetylcholine receptor (mAChR) agonist, induces the release of AQP5. Changes in salivary AQP5 levels after cevimeline administration occur simultaneously with changes in saliva flow rate. AQP5 and lipid rafts are released separately from human salivary glands upon M3 mAChR stimulation. In patients with diabetes mellitus or Sjögren’s syndrome, a decrease in salivary secretion occurs concomitantly with low salivary AQP5 levels. Salivary AQP5 levels correlate with salivary secretion in both healthy and disease states, suggesting that changes in salivary AQP5 levels can be used as an indicator of salivary flow rate and the effect of M3 mAChR agonists on human salivary glands.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
56
Issue
Supplement
Start Page
350
End Page
353
Sort Key
350
Published Date
2009-12
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences