ID 111513
Author
Tanioka, Rie Osaka National Hospital
Yamamoto, Yoshihiko Osaka National Hospital
Sakai, Mio Osaka National Hospital
Makie, Toshio Osaka National Hospital
Mori, Masahiko Osaka National Hospital
Uehira, Tomoko Osaka National Hospital
Shirasaka, Takuma Osaka National Hospital
Keywords
reversible posterior leukoencephalopathy syndrome (RPLS)
HIV
highly active antiretrovial therapy (HAART)
Content Type
Journal Article
Description
Reversible Posterior Leukoencephalopathy Syndrome (RPLS) is an uncommon neurological disorder which shows the diffuse edema in white matter of occipital lobe of brain. In this report, we describe a RPLS case with Human Immunodeficiency Virus (HIV) infection, whose lesion was improved with Highly Active Antiretroviral Therapy (HAART). A HIV-infected man, who was diagnosed as a mental deterioration with Central Pontine Myelinolysis (CPM) appearing high intensity pontine lesion in brain Magnetic Resonance Imaging (MRI), improved with HAART. No episode of hyponatremia or hypertension was observed in his clinical course. Evaluation of apparent diffusion coefficient (ADC) mapping in diffusion weight imaging (DWI) was performed in brain MRI at the onset and four months after commencement of HAART. ADC mapping enabled to interpret the pontine lesion as RPLS. HAART improved the mental deterioration within two weeks and the elevated ADC value at the onset was normalized at four-month clinical course.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
54
Issue
1-2
Start Page
191
End Page
194
Sort Key
191
Published Date
2007-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher