ID 111530
Title Alternative
Parathyroid cells : structure or Ca2+ sensing receptor
Author
Saito, Shiro The University of Tokushima
Keywords
Ca2+ sensing receptor
Parathyroid
G protein coupled receptor
Familial hypocalciuric hypercalcemia
Autosomal dominant hypocalcemia
Content Type
Journal Article
Description
Using expression in Xenopus oocytes, Brown et al. cloned a bovine parathyroid Ca2+ sensing receptor (BoPCaRl). The 1,085 amino acid membrane protein is included in a class of putative seven transmembrane spanning structures that activate the phosphoinositol pathway through G proteins. Receptor activation presumably elevates intracellular Ca2+ to inhibit secretion of PTH. BoPCaRl has a big extracellular domain at the amino terminus. BoPCaRl is most similar to the metabotropic glutamate receptor. BoPCaRl mRNA is found in cells that have well known Ca2+ sensing function. Inheritance of one inactive Ca2+ sensing receptor gene causes familial hypocalciuric hypercalcemia (FHH) and autosomal dominant hypocalcemia. Mutations in the extracellular domain and in a portion of the third intracellular loop domain decrease the receptor’s sensitivity, causing FHH. Extracellular domain mutations increase the receptor’s activity at low Ca2+ concentration to cause autosomal familial hypocalcemia.
Journal Title
Japanese journal of clinical medicine
ISSN
00471852
NCID
AN00198641
Publisher
日本臨牀社
Volume
53
Issue
4
Start Page
805
End Page
810
Published Date
1995-04
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences