Familial pituitary tumors
Yoshimoto, Katsuhiko The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Saito, Shiro The University of Tokushima
Familial pituitary adenomas
Familial pituitary tumors are relatively rare. Most commonly, they occur as a part of multiple endocrine neoplasia type 1 (MEN 1). However, familial pituitary adenomas unrelated MEN 1 (familial pituitary adenomas) are extremely rare. In review of MEN 1 in Japan, 60% of the patients with MEN 1 had pituitary tumors. Only 45 cases of familial pituitary adenomas have been reported from 20 families. In our review of familial pituitary adenomas, 30 (67%) of 45 reported cases are acromegaly or gigantism. This incidence is much higher than 28% in MEN 1 patients with pituitary tumors. Allelic deletions at 11q13 were identified in MEN 1 associated pituitary adenomas and familial pituitary adenomas in two gigantism brothers.
Japanese journal of clinical medicine
jjcm_53_11_2691.pdf 4.04 MB