ID 111531
Title Alternative
Familial pituitary tumors
Author
Saito, Shiro The University of Tokushima
Keywords
MEN 1
Familial pituitary adenomas
Acromegaly
Prolactinoma
Allelic deletion
11q13
Content Type
Journal Article
Description
Familial pituitary tumors are relatively rare. Most commonly, they occur as a part of multiple endocrine neoplasia type 1 (MEN 1). However, familial pituitary adenomas unrelated MEN 1 (familial pituitary adenomas) are extremely rare. In review of MEN 1 in Japan, 60% of the patients with MEN 1 had pituitary tumors. Only 45 cases of familial pituitary adenomas have been reported from 20 families. In our review of familial pituitary adenomas, 30 (67%) of 45 reported cases are acromegaly or gigantism. This incidence is much higher than 28% in MEN 1 patients with pituitary tumors. Allelic deletions at 11q13 were identified in MEN 1 associated pituitary adenomas and familial pituitary adenomas in two gigantism brothers.
Journal Title
Japanese journal of clinical medicine
ISSN
00471852
NCID
AN00198641
Publisher
日本臨牀社
Volume
53
Issue
11
Start Page
2691
End Page
2696
Published Date
1995-11
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences