ID 111554
Author
Sekiyama, Atsuo The University of Tokushima|Hyogo Collage of Medicine|Osaka University|Esaka Hospital
Ueda, Haruyasu Hyogo Collage of Medicine
Kashiwamura, Shin-ichiro Hyogo Collage of Medicine
Kawai, Kaori The University of Tokushima
Okamura, Haruki Hyogo Collage of Medicine
Keywords
stress
interleukin (IL)
adrenocorticotropic hormone (ACTH)
hypothalamus-pituitary-adrenal (HPA) axis
Content Type
Journal Article
Description
Psychological/physical stresses have been reported to exacerbate auto-immune and inflammatory diseases. To clarify a mechanism by which non-inflammatory stresses disrupt host defenses, responses to immobilization stress in mice were investigated, focusing on the role of a multifunctional cytokine, interleukin-18 (IL-18). In the adrenal cortex, the stress induced IL-18 precursor proteins (pro-IL-18) via ACTH and a superoxide-mediated caspase-1 activation pathway, resulting in conversion of pro-IL-18 to the mature form which was released into plasma. Inhibitors of caspase-1, reactive oxygen species and P38 MAPK prevented stress-induced accumulation of plasma IL-18. These inhibitors also blocked stress-induced IL-6 expression. This, together with the observation that IL-6was not induced in stressed-IL-18 deficient mice, showed that IL-6 induction by stress is dependent on IL-18. In stressed organisms, IL-18 may influence pathological and physiological processes. Controlling the caspase-1 activating pathway to suppress IL-18 levels may provide preventative means against stress-related disruption of host defenses.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
52
Issue
Supplement
Start Page
236
End Page
239
Sort Key
236
Published Date
2005-11
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences