ID 111564
Author
Asanuma, Kotaro North Shore-Long Island Jewish Health System|North Shore University Hospital and New York University School of Medicine
Carbon-Correll, Maren North Shore-Long Island Jewish Health System|North Shore University Hospital and New York University School of Medicine
Eidelberg, David North Shore-Long Island Jewish Health System|North Shore University Hospital and New York University School of Medicine
Keywords
positron emission tomography (PET)
diffusion tensor imaging (DTI)
dystonia
network analysis
Content Type
Journal Article
Description
Functional neuroimaging, such as positron emission tomography(PET) and functional magnetic resonance imaging (fMRI), provides a valuable technique for detecting regional changes in brain metabolic activity associated with human disease. These techniques have been applied in different dystonic disorders including primary generalized dystonia and dopa-responsive dystonia (DRD), as well as focal dystonic syndromes such as torticollis, writer’s cramp, and blepharospasm. A common finding is abnormality of the basal ganglia and associated outflow pathways to sensorimotor cortex and other regions involved with motor performance. Other recent imaging research has utilized diffusion-based MRI techniques to localize distinct microstructural abnormalities in dystonia patients and gene carriers. This presentation will focus on an integrated approach to understanding the pathophysiology of this genetic and biochemically diverse disorder.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
52
Issue
Supplement
Start Page
272
End Page
279
Sort Key
272
Published Date
2005-11
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher