ID 111587
Author
Sakakibara, Hiroyuki The University of Tokushima
Ishida, Kaori The University of Tokushima
Izawa, Yuki The University of Tokushima
Minami, Yuko The University of Tokushima
Saito, Satomi The University of Tokushima
Butterweck, Veronika University of Florida
Keywords
depression
forced swimming test
brain function
serotonergic ratio
ERK1/2
Content Type
Journal Article
Description
Chronic stress has been reported to be an essential factor for depression. In this study, the effect of forced swimming stress on neurotransmitters and cellular signaling pathway contributing to brain functions was investigated using the forced swimming test (FST) in order to understanding of mechanisms to regulate stress signals in brain. Antidepressant drug, imipramine, significantly reduced the immobility time of male rats in the FST by 85% at a dose of 15mg/kg for 2 weeks. This result indicated that the swimming stress caused a depressed state in the rats without administration of imipramine. Swimming stress significantly lowered the serotonergic ratio and also markedly enhanced the phosphorylation of ERK1/2 in the hypothalamus region compared to the rats without FST. These phenomena maybe included in key mechanisms of the development of depression.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
52
Issue
Supplement
Start Page
300
End Page
301
Sort Key
300
Published Date
2005-11
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences