ID 111615
Author
Koyama, A. Hajime The University of Tokushima
Irie, Hiroshi Teikyo University
Hata, So The University of Tokushima
Iida, Shinya The University of Tokushima
Akari, Hirofumi The University of Tokushima
Keywords
apoptosis
antiapoptosis
virus infection
host defense mechanism
TNF
cytokine
VSV
HSV-1
HIV
Content Type
Journal Article
Description
Many animal viruses are known to induce apoptosis in infected cells. This virus-induced apoptosis has been often described as a mechanism of host defense against virus infection, based on the finding that mutants of an insect virus with the ability to induce extensive apoptosis in some cells cannot grow in the same cells. In animal virus infection, we have shown that (1) viruses can somehow overcome this defense mechanism and that (2) virus multiplication in the apoptotic cells is not as completely suppressed as in the insect virus infection. These results suggest that, in the case of animal viruses, the virus-induced apoptosis does not play the same role in the host defense system as in insect cells. However, by examining the virus infection under the conditions comparable to the infection in vivo, we demonstrated the defensive role of apoptosis in animal virus infection.
Journal Title
The Journal of Medical Investigation
ISSN
13431420
NCID
AA11166929
Publisher
The University of Tokushima School of Medicine
Volume
45
Issue
1-4
Start Page
37
End Page
45
Sort Key
37
Published Date
1998-08
EDB ID
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences