ID 111620
Author
Hayashi, Shigehito The University of Tokushima
Shibata, Hiroshi The University of Tokushima
Keywords
contrast medium
iomeprol
hemofiltration
hemodiafiltration
Content Type
Journal Article
Description
The contrast medium-removing effect of hemofiltration (HF) and hemodiafiltration (HDF) was experimentally investigated using a bovine blood tank model. HF and HDF were performed at a blood flow rate of 100ml/min with a polysulfone hemofilter (PS filter-CF ; membrane area : 0.7 m2). Two hundred milliliters of iomeprol (300 mgI/ml) was administered by a single injection into 4 liters of bovine blood. The blood half-lives of iomeprol were 1.0 hr for the high flow rate HDF group [replacement fluid flow rate (QF) : 10 ml/min and dialysate flow rate (QD) : 40 ml/min], 1.8 hr for the HDF group (QF : 10 ml/min and QD : 10 ml/min), and 3.8 hr for the HF group (QF : 10 ml/min). The mean clearance rates were 39.7 ml/min for the high flow rate HDF group, 21.4 ml/min for the HDF group, and 12.0 ml/min for the HF group. Iomeprol was mostly excreted in the waste fluid. It is concluded that HDF can remove contrast media more effectively than HF.
Journal Title
The Journal of Medical Investigation
ISSN
13431420
NCID
AA11166929
Publisher
The University of Tokushima School of Medicine
Volume
45
Issue
1-4
Start Page
87
End Page
93
Sort Key
87
Published Date
1998-08
EDB ID
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences