ID 111637
Author
Watanabe, Tsutomu The University of Tokushima
Takaue, Yoichi The University of Tokushima
Kawano, Yoshifumi The University of Tokushima
Keywords
peripheral blood stem cell transplantation
mobilization
autologous
allogeneic
CD34+cell
Content Type
Journal Article
Description
Patients with a number of different malignancies have been treated with high-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT). PBSC already replaced bone marrow as the source of autologous hematopoietic progenitor support. This is due to ease of collection, rapid engraftment and less possibility of tumor cell contamination in the graft. Furthermore, allogeneic transplantation of granulocyte colony-stimulating factor (G-CSF) mobilized PBSC is now being increasingly performed. Recent advance of clinical PBSCT and new strategies are stressed in this review. New strategies include CD 34+cell purification, ex vivo expansion of PBSC and PBSC as a target cell for gene therapy. Major future advance may occur better understanding of the mechanism of mobilization and the biology of PBSC.
Journal Title
The Journal of Medical Investigation
ISSN
13431420
NCID
AA11166929
Publisher
The University of Tokushima School of Medicine
Volume
44
Issue
1-2
Start Page
25
End Page
31
Sort Key
25
Published Date
1997-08
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher