ID 111638
Author
Maekawa, Yoichi The University of Tokushima
Himeno, Kunisuke The University of Tokushima
Katunuma, Nobuhiko Tokushima Bunri University
Keywords
cathepsin B
antigen-processing
Th1/Th2
experimental leishmaniasis
Content Type
Journal Article
Description
BALB/c mice are genetically susceptible to infection with Leishmania major (L. major). When such mice infected with L. major were treated with specific inhibitors of cathepsin B, a lysosomal cysteine protease that digests exogenous antigenic proteins, the mice acquired resistance against L. major infection. T cells from these mice produced large amounts of IFN-γ and low amounts of IL-4 as compared with those of untreated BALB/c mice. In addition, the mice treated with cathepsin B inhibitor produced a high titer of IgG2a specific antibodies and only low titers of IgG1 and IgE antibodies. This type of response is in contrast with the high specific IgG1 or IgE antibody responses which are the usual antibody responses in BALB/c mice infected with L. major. These findings indicate that cathepsin B may be critically involved in processing antigens of L. major to promote exclusively the development of Th2 type CD4+T cell responses.
Journal Title
The Journal of Medical Investigation
ISSN
13431420
NCID
AA11166929
Publisher
The University of Tokushima School of Medicine
Volume
44
Issue
1-2
Start Page
33
End Page
39
Sort Key
33
Published Date
1997-08
EDB ID
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher