ID 111649
Author
Furumoto, Hiroyuki The University of Tokushima KAKEN Search Researchers
Kamada, Masaharu The University of Tokushima
Katsura, Masumi The University of Tokushima
Aono, Toshihiro The University of Tokushima
Keywords
ATL
triple malignancies
IL-2
IL-2 inhibitor
Content Type
Journal Article
Description
A patient with triple malignancies is reported, who presented cervical cancer, vulvar cancer and adult T cell leukemia (ATL). ATL was diagnosed as a smouldering type, because antibody to human T cell leukemia virus associated antigen (ATLA) was positive with a titer of 1 : 160. Although her malignant cells had an OKT 4+8-3+Tac+ phenotype, the cells did not display helper T cell functions. Namely they showed no response to Phytohemagglutinin (PHA) and Interleukin 2 (IL-2) and suppressed the PWM driven IgG synthesis of B cells obtained from healthy donor. They did not produce IL-2 by stimulation with PHA and phorbol myristate acetate (PMA). Furthermore, these ATL cells were producing IL-2 inhibitor like factors. As synchronous triple malignancies are extremely rare, two gynecologic cancers seem to ascribe to the suppressing state of the immunosurveillance mechanism by viral infection.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
The University of Tokushima School of Medicine
Volume
44
Issue
1-2
Start Page
99
End Page
102
Sort Key
99
Published Date
1997-08
EDB ID
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital