ID 111861
Title Alternative
Electron microscopic studies of Acanthamoeba : 2 Morphological changes of cultured Acanthamoeba due to anti-amoebic agents
Author
Yano, Masahiko The University of Tokushima
Kato, Toshihiko The University of Tokushima
Mimura, Yasuo The University of Tokushima
Keywords
Acanthamoeba
electron microscope
fradiomycin
polyhexamethylene biguanide (PHMB)
Content Type
Journal Article
Description
Morphological changes of Acanthamoeba in Peptone-Yeast-Glucose medium containing anti-amoebic agents were studied with transmission electron microscope.
In fradiomycin-treated amoeba, decrease of acanthopodia, vacuolar formation in the ectoplasm and cell collapse were observed. In polyhexamethylene biguanide (PHMB)-treated amoeba, rupture of plasma membrane and degeneration of mitochondria were observed at the early stage. These results indicate that PHMB is more effective than fradiomycin for the treatment of Acanthaoeba keratitis.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
52
Issue
2
Start Page
33
End Page
39
Sort Key
33
Published Date
1996-04-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences