ID 111943
Title Alternative
Development of Stimulus-responsive Amino Acids and Their Application to Chemical Biology Use
Author
Keywords
peptide bond cleavage
stimulus-responsive amino acid
trimethyl lock
Content Type
Journal Article
Description
An understanding of the physiological significance of peptides and proteins is indispensable in the fields of life sciences and drug development. Recently, methods for controlling peptide and protein activities using stimuli such as UV irradiation have been attracting much attention because of their potential for clarifying the physiological roles of the peptides/proteins. In this context, we have developed a stimulus-responsive amino acid that induces peptide-bond cleavage after exposure to a stimulus. Although it has previously been reported that stimulus-responsive units can respond to a specific stimulus, our stimulus-responsive amino acid is potentially applicable to any stimulus simply by changing the protective group. In this review, the design and synthesis of stimulus-responsive amino acids are described. Their applications in chemical biology, including their use for spatiotemporal control of the activity of peptides in living cells, are also reported.
Journal Title
Journal of the Pharmaceutical Society of Japan
ISSN
13475231
00316903
NCID
AA11696503
AN00284903
Publisher
公益社団法人 日本薬学会
Volume
132
Issue
9
Start Page
1075
End Page
1082
Published Date
2012
Rights
© 2012 The Pharmaceutical Society of Japan
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
jpn
TextVersion
Publisher
departments
Pharmaceutical Sciences