ID 111992
Author
Iwata, Koichi Nihon University
Terayama, Ryuji Okayama University
Imamura, Yoshiki Nihon University
Maruhama, Kotaro Okayama University
Shinoda, Masamichi Nihon University
Tsuboi, Yoshiyuki Nihon University
Kondo, Masahiro Nihon University
Honda, Kuniya Nihon University
Katagiri, Ayano Nihon University
Sugimoto, Tomosada Okayama University
Keywords
Orofacial pathological pain
Nerve injury
Glial cell
Trigeminal sensory nuclear complex
Neuroimaging
Content Type
Journal Article
Description
Background: Trigeminal nerve injury or orofacial inflammation causes severe pain in the orofacial regions innervated by uninjured nerves or uninflamed tissues as well as injured or inflamed tissues. Pathological orofacial pain associated with trigeminal nerve injury or inflammation is difficult to diagnose and treat.
Highlights: To develop appropriate treatments for patients with orofacial pathological pain, various animal models of trigeminal nerve injury or orofacial inflammation have been developed. Further, the possible mechanisms involving the trigeminal ganglion (TG), trigeminal spinal subnucleus caudalis (Vc), and upper cervical spinal cord (C1-C2) have been studied.
Conclusions: 1) Neurotransmitters released from the somata of TG neurons are involved in peripheral sensitization. 2) Neurotransmitter release from TG neurons is decreased by botulinum toxin-type A administration, suggesting that this toxin suppressed neurotransmitter release and alleviated the neuropathic pain-related behavior. 3) Altered states of glial cells and nociceptive neurons, in the Vc and C1-C2 are involved in pathological orofacial pain associated with trigeminal nerve injury or orofacial inflammation. 4) The trigeminal sensory nuclear complex, especially the trigeminal spinal subnucleus oralis, is involved in normal and pathological orofacial pain conditions after peripheral nerve injury. 5) Neuroimaging analyses have suggested functional changes in the central and peripheral nervous systems in neuropathic pain conditions.
Journal Title
Journal of Oral Biosciences
ISSN
13490079
NCID
AA11896386
AA12057113
Publisher
The Japanese Association for Oral Biology
Volume
57
Issue
1
Start Page
27
End Page
36
Published Date
2014-10-14
Remark
© 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Oral Sciences