ID 112010
Title Alternative
A clinical investigation on chronic hepatitis C with chronic thyroiditis
Author
Mitani, Hiroaki Mitani Clinic
Keywords
HCV
chronic hepatitis C
chronic thyroiditis
antithyroid antibody
Content Type
Journal Article
Description
In recent years, the complication with chronic thyroiditis in patients of chronic hepatitis C were reported, and further, induction of thyroid dysfunction by administration of interferon has been shown. Therefore, we tested antithyroid antibody in 44 patients with chronic hepatitis C (24 females and 20 males; 61.1 years old in average), further HCV-RNA and anti-GOR antibody in 33, 24 subjects respectively. As a result, nine patients (20.2%; 6 females and 3 males) were antithyroid antibody positive, which is higher than the positive rate, 6.3% in normal subjects in Tokushima prefecture ( x2 test, p<0.01).
In the antithyroid antibody positive gyoup, the HCV-RNA level was higher than 0.5 Meq/ml in seven of nine subjects (77.8%), whereas in the antithyroid antibody negative group (35 subjects; 18 females and 17 males), six of 24 subjects (25.0%) tested showed higher level than 0.5 Meq/ml, i,e., significant change in the HCV-RNA level was found in antithyroid antobody positive group (Wilcoxon test, p<0.05). And there was not higher the anti-GOR antibody level of patients with antithyroid antibody positive group in comparison with negative group, however it was significant relationship between antimicrosomal antibody and anti-GOR antibody level in five patients with antithyroid antibody positive group (r=+0.891, p<0.05).
This study may be indicated that chronic hepatitis C probably complicate chronic thyroiditis by immunologicaly several cytokines to be related with anti-GOR antibody to be linked antimicrosomal antibody and self reactive T cell, to have been expressed class II antigen in thyroid tissue. Accordingly, these results suggest the induction of chronic thyroiditis by high HCVnemia.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
53
Issue
6
Start Page
242
End Page
247
Sort Key
242
Published Date
1997-12-25
FullText File
language
jpn
TextVersion
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