ID 112065
Title Alternative
The effects of insulin-induced hypoglycemia on the human VEP (Visual Evoked Potential) and EEG
Author
Kawamura, Ichiro The University of Tokushima
Ito, Yoshinobu The University of Tokushima
Okura, Masao The University of Tokushima
Ikuta, Takumi The University of Tokushima
Edagawa, Koji The University of Tokushima
Keywords
visual evoked potential
EEG
insulin-induced hypoglycemia
lateral geniculate body
brainstem
Content Type
Journal Article
Description
The effects of insulin-induced hypoglycemia on central nervous system were studied by visual flash evoked potential (VEP), with 8 schizophrenic patients (31~47 y.o.), during the 'Kleine Insulinbehandlung'. In the three experimental sessions on different days, human regular insulin were injected subcutaneously to each patient, whose consciousness level were lowered to the stage of somnolence and recovered after intake of a solution of glucose (100 g). EEG containing VEPs evoked by flash stimuli once every 5 seconds were derived from the two derivations (2 nd ch : O1→A1+2, 5 th ch : O1→Cz). In the experimental session, EEG containing VEPs were recorded before and 20, 40, 60, 80, 100 and 120 min after the injection of insulin, and 20 min after intake of glucose. Consecutive changes of group mean VEP were studied. Individual VEPs were subjected to the component analysis, and to the statistical assessment together with EEG power%. The following results were obtained.
1. The long latency components of VEP significantly increased in latency and significantly deceased in peak-to-peak amplitude in the early stage after the injection of insulin. These findings indicate the inhibitory effects of insulin-induced hypoglycemia on the cerebral cortex in the early stage.
2. The short latency components of VEP significantly increased in the latency of N2 and significantly decreased in the peak-to-peak amplitude of P2-N2 in the latter stage. In EEG, the power% of δ and θ frequency bands significantly increased and that of α 1~β 2 significantly decreased in the latter stage. These findings indicate the inhibitory effects on the lateral geniculate body due to the decline of the brainstem activity, in the latter stage of insulin-induced hypoglycemia.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
54
Issue
1
Start Page
89
End Page
98
Sort Key
89
Published Date
1998-02-25
FullText File
language
jpn
TextVersion
Publisher