ID 112095
Title Alternative
The antitumor effect of suramin to the head and neck cancer
スラミンの抗腫瘍効果
Author
Kondo, Akio The University of Tokushima
Keywords
suramin
antitumor effect
head and neck cancer
cell proliferation
cell differentiation
Content Type
Journal Article
Description
Suramin was originally developed as an antiparasitic drug for African trypanosomiasis. Subsequently, it has been found to have antitumor effects to various neoplasmas such as adrenal cancer and prostate cancer. However, its effect on the head and neck cancer is unknown. This study was perfomed to investigate the effects of suramin on the head and neck cancer.
SCC-25 cells and FRO cells were used as a representative of malignant cell, and L cells were used as a representative of normal cell in this study. Each cell line was cultured together with suramin solution at various concentration (0, 50, 100, 200, 300, 500, 1000 μM) at 37°C for 72 hours and was stained by Papanicolaou method.
The proliferation of SCC-25 cells and FRO cells was inhibited by suramin solution at more than 100 μM and 50 μM concentration respectively. However, The proliferation of L cells was not inhibited until 300 μM concentration. Morphologycally, suramin induced the differentiation of SCC-25 cells and FRO cells. But the morphology of L cells were not changed by suramin.
It is concluded that suramin can be an effective antitumor drug for the head and neck cancer.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
54
Issue
5
Start Page
323
End Page
332
Sort Key
323
Published Date
1998-10-25
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language
jpn
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