頭頸部癌に対するスラミンの抗腫瘍効果

Suramin was originally developed as an antiparasitic drug for African trypanosomiasis. Subsequently, it has been found to have antitumor effects to various neoplasmas such as adrenal cancer and prostate cancer. However, its effect on the head and neck cancer is unknown. This study was perfomed to investigate the effects of suramin on the head and neck cancer.
SCC-25 cells and FRO cells were used as a representative of malignant cell, and L cells were used as a representative of normal cell in this study. Each cell line was cultured together with suramin solution at various concentration (0, 50, 100, 200, 300, 500, 1000 μM) at 37°C for 72 hours and was stained by Papanicolaou method.
The proliferation of SCC-25 cells and FRO cells was inhibited by suramin solution at more than 100 μM and 50 μM concentration respectively. However, The proliferation of L cells was not inhibited until 300 μM concentration. Morphologycally, suramin induced the differentiation of SCC-25 cells and FRO cells. But the morphology of L cells were not changed by suramin.
It is concluded that suramin can be an effective antitumor drug for the head and neck cancer.