ID 112097
Title Alternative
Molecular nutrition of intestinal oligopeptide transporter
Author
Shiraga, Toshiyuki The University of Tokushima
Tanaka, Hiroko The University of Tokushima
Keywords
H+-dependent oligopeptide transporter
di- and tripeptides
promoter region
drug delivery system
intestinal mucosal injury
Content Type
Journal Article
Description
The oligopeptide transporter (PepT 1), which is located in the intestinal brush border membrane, provides a major mechanism for protein absorption in the small intestine. Molecular cloning of the gene encoding rat PepT 1 has predicted a 78,710 -kilodalton protein consisting of 710 amino acid residues and processing 12 putative membrane-spanning domains. The characterization of its function has shown that (1) it transports dipeptides, tripeptides, and β-lactam antibiotics but not free amino acids or peptides with more than four amino acid residues, and (2) its driving force for uphill transport requires proton binding. A human intestinal cell line (Caco-2) has been used to investigate the molecular regulation of the PepT 1 gene. These studies suggest that amino acids directly stimulate the promoter activity of the PepT 1 gene. Thus, PepT 1 plays important roles in nutritional and pharmacological therapies.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
54
Issue
5
Start Page
341
End Page
348
Sort Key
341
Published Date
1998-10-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences