ID 112231
Title Alternative
Molecular actions of flavonoids conjugates
Author
Keywords
polyphenol
flavonoid
glucuronide
inflammation
atherosclerosis
Content Type
Journal Article
Description
Many papers have suggested the health-beneficial activity of natural dietary polyphenols to prevent chronic diseases and aging processes in humans. It is generally recognized that polyphenols are absorbed from the intestines and metabolized into the phase-II conjugates, i.e., the glucuronides and sulfates. For example, a major dietary flavonoid, quercetin, abundant in onion and buckwheat, is metabolized after oral intake into its conjugates, such as quercetin-3-O-glucuronide and quercetin-3’-O-sulfate, whereas no aglycone was found in the human plasma. Therefore, to understand the mechanisms of the biological activity of quercetin in vivo, we should focus on the molecular actions of these conjugates. In the last decade, we have demonstrated the unique actions of quercetin-3-O-glucuronide at sites of inflammation, including specific accumulation in macrophages and the following deconjugation into active aglycone, catalyzed by the macrophage-derived β-glucuronidase. This review summarizes recent findings regarding the anti-inflammatory mechanisms of quercetin conjugates in macrophages and propose a possible strategy for the effective utilization of natural polyphenols in our daily diet for prevention of age-related chronic diseases.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA12022913
AA11166929
Publisher
Faculty of Medicine Tokushima University
Volume
65
Issue
3-4
Start Page
162
End Page
165
Sort Key
162
Published Date
2018-08
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences