ID 112374
Title Alternative
The antitumor activity of xanthohumol
Author
Shikata, Yuki Keio University
Komatsu, Masato Tokushima University
Katoh, Hiroto Tokyo Medical and Dental University|JST
Sato, Reiko Tokyo Medical and Dental University
Kanagaki, Shuhei Keio University
Okazaki, Yasumasa Nagoya University
Toyokuni, Shinya Nagoya University
Tashiro, Etsu Keio University
Ishikawa, Shumpei Tokyo Medical and Dental University
Imoto, Masaya Keio University
Keywords
Adenylate cyclase
antitumor activity
apoptosis
valosin-containing protein
xanthohumol
Content Type
Journal Article
Description
Xanthohumol (XN), a simple prenylated chalcone, can be isolated from hops and has the potential to be a cancer chemopreventive agent against several human tumor cell lines. We previously identified valosin-containing protein (VCP) as a target of XN; VCP can also play crucial roles in cancer progression and prognosis. Therefore, we investigated the molecular mechanisms governing the contribution of VCP to the antitumor activity of XN. Several human tumor cell lines were treated with XN to investigate which human tumor cell lines are sensitive to XN. Several cell lines exhibited high sensitivity to XN both in vitro and in vivo. shRNA screening and bioinformatics analysis identified that the inhibition of the adenylate cyclase (AC) pathway synergistically facilitated apoptosis induced by VCP inhibition. These results suggest that there is crosstalk between the AC pathway and VCP function, and targeting both VCP and the AC pathway is a potential chemotherapeutic strategy for a subset of tumor cells.
Journal Title
Cancer Science
ISSN
13497006
Publisher
Japanese Cancer Association
Volume
108
Issue
4
Start Page
785
End Page
794
Published Date
2017-01-25
Rights
© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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language
eng
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departments
Institute of Advanced Medical Sciences