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ID 112392
Author
Murakami, Chiaki Tokushima University
Content Type
Journal Article
Description
Postoperative nausea and vomiting (PONV) occur in 30โ€“50% of patients undergoing general anesthesia and in 70โ€“80% of high PONV risk patients. In this study, we investigated the efficacy of fosaprepitant, a neurokinin-1 (NK1) receptor antagonist, compared to ondansetron, a selective 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, in moderate to high PONV risk patients from our previous randomized controlled trials. Patients (171 patients from 4 pooled studies) with the Apfel simplified score โ‰ฅ 2 and undergoing general anesthesia were randomly allocated to receive intravenous fosaprepitant 150 mg (NK1 group, ๐‘› = 82) and intravenous ondansetron 4 mg (ONS group, ๐‘› = 89) before induction of anesthesia. Incidence of vomiting was significantly lower in the NK1 group compared to the ONS group 0โ€“2, 0โ€“24, and 0โ€“48 hours after surgery (2 versus 17%, 2 versus 28%, and 2 versus 29%, resp.). However, no significant differences in PONV, complete response, rescue antiemetic use, and nausea score were observed between groups 0โ€“48 hours after surgery. In moderate to high PONV risk patients, fosaprepitant decreased the incidence of vomiting and was superior to ondansetron in preventing postoperative vomiting 0โ€“48 hours after surgery.
Journal Title
BioMed Research International
ISSN
23146133
23146141
Publisher
Hindawi
Volume
2017
Start Page
5703528
Published Date
2017-12-19
Rights
Copyright ยฉ 2017 Chiaki Murakami et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital