ID 112399
Author
Tajima, Atsushi Tokushima University|Kanazawa University KAKEN Search Researchers
Yamamori, Hidenaga Osaka University
Yasuda, Yuka Osaka University
Fujimoto, Michiko Osaka University
Shimodera, Shinji Kochi Medical School
Nakazawa, Takanobu Osaka University
Kikuchi, Masataka Osaka University
Nakaya, Akihiro Osaka University
Hashimoto, Hitoshi Osaka University
Hashimoto, Ryota Osaka University
Keywords
schizophrenia
DNA methylation
clozapine
Content Type
Journal Article
Description
Clozapine is an atypical antipsychotic, that is established as the treatment of choice for treatment-resistant schizophrenia (SCZ). To date, no study investigating comprehensive DNA methylation changes in SCZ patients treated with chronic clozapine has been reported. The purpose of the present study is to reveal the effects of clozapine on DNA methylation in treatment-resistant SCZ. We conducted a genome-wide DNA methylation profiling in peripheral leukocytes (485,764 CpG dinucleotides) from treatment-resistant SCZ patients treated with clozapine (n = 21) in a longitudinal study. Significant changes in DNA methylation were observed at 29,134 sites after one year of treatment with clozapine, and these genes were enriched for “cell substrate adhesion” and “cell matrix adhesion” gene ontology (GO) terms. Furthermore, DNA methylation changes in the CREBBP (CREB binding protein) gene were significantly correlated with the clinical improvements. Our findings provide insights into the action of clozapine in treatment-resistant SCZ.
Journal Title
International Journal of Molecular Sciences
ISSN
14220067
16616596
NCID
AA12038549
Publisher
MDPI
Volume
18
Issue
3
Start Page
632
Published Date
2017-03-14
Rights
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences