Ono, Mitsuaki Okayama University
Oshima, Masamitsu Okayama University|Tokyo University of Science|RIKEN Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ogawa, Miho Tokyo University of Science|RIKEN|Organ Technologies Inc.
Sonoyama, Wataru Okayama University
Hara, Emilio Satoshi Okayama University
Oida, Yasutaka Okayama University
Shinkawa, Shigehiko Okayama University
Nakajima, Ryu Okayama University
Mine, Atsushi Okayama University|Osaka University
Hayano, Satoru Okayama University
Fukumoto, Satoshi Tohoku University
Kasugai, Shohei Tokyo Medical and Dental University
Yamaguchi, Akira Tokyo Medical and Dental University|Tokyo Dental College
Tsuji, Takashi Tokyo University of Science|RIKEN|Organ Technologies Inc.
Kuboki, Takuo Okayama University
Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ using three-dimensional cell manipulation in vitro. Recently, many basic studies of whole-tooth replacement using three-dimensional cell manipulation have been conducted in a mouse model. Further evidence of the practical application to human medicine is required to demonstrate tooth restoration by reconstructing bioengineered tooth germ using a postnatal large-animal model. Herein, we demonstrate functional tooth restoration through the autologous transplantation of bioengineered tooth germ in a postnatal canine model. The bioengineered tooth, which was reconstructed using permanent tooth germ cells, erupted into the jawbone after autologous transplantation and achieved physiological function equivalent to that of a natural tooth. This study represents a substantial advancement in whole-organ replacement therapy through the transplantation of bioengineered organ germ as a practical model for future clinical regenerative medicine.
Supplemental Information : srep_7_44522_s1.pdf
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srep_7_44522.pdf 1.66 MB
srep_7_44522_s1.pdf 1.25 MB