ID 112433
Author
Ono, Mitsuaki Okayama University
Ogawa, Miho Tokyo University of Science|RIKEN|Organ Technologies Inc.
Sonoyama, Wataru Okayama University
Hara, Emilio Satoshi Okayama University
Oida, Yasutaka Okayama University
Shinkawa, Shigehiko Okayama University
Nakajima, Ryu Okayama University
Mine, Atsushi Okayama University|Osaka University
Hayano, Satoru Okayama University
Fukumoto, Satoshi Tohoku University
Kasugai, Shohei Tokyo Medical and Dental University
Yamaguchi, Akira Tokyo Medical and Dental University|Tokyo Dental College
Tsuji, Takashi Tokyo University of Science|RIKEN|Organ Technologies Inc.
Kuboki, Takuo Okayama University
Content Type
Journal Article
Description
Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ using three-dimensional cell manipulation in vitro. Recently, many basic studies of whole-tooth replacement using three-dimensional cell manipulation have been conducted in a mouse model. Further evidence of the practical application to human medicine is required to demonstrate tooth restoration by reconstructing bioengineered tooth germ using a postnatal large-animal model. Herein, we demonstrate functional tooth restoration through the autologous transplantation of bioengineered tooth germ in a postnatal canine model. The bioengineered tooth, which was reconstructed using permanent tooth germ cells, erupted into the jawbone after autologous transplantation and achieved physiological function equivalent to that of a natural tooth. This study represents a substantial advancement in whole-organ replacement therapy through the transplantation of bioengineered organ germ as a practical model for future clinical regenerative medicine.
Journal Title
Scientific Reports
ISSN
20452322
Publisher
Springer Nature
Volume
7
Start Page
44522
Published Date
2017-03-16
Remark
Supplemental Information : srep_7_44522_s1.pdf
Rights
© The Author(s) 2017
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences