ID 112455
Title Alternative
Effects of DHT injection
Author
Yano, Kiyohito Tokushima University
Mayila, Yiliyasi Tokushima University
Keywords
Dihydrotestosterone
estradiol
kisspeptin
GnIH
Content Type
Journal Article
Description
To clarify the direct effects of androgens, the changes in the hypothalamic levels of reproductive and appetite regulatory factors induced by chronic dihydrotestosterone (DHT) administration were evaluated in female rats. DHT treatment increased the BW and food intake of the ovariectomized rats, but not the estradiol (E2)-treated rats. DHT administration suppressed the expression of a hypothalamic anorexigenic factor. Although the kisspeptin (Kiss1) mRNA levels of the anterior hypothalamic block (the anteroventral periventricular nucleus, AVPV) were increased in the E2-treated rats, DHT administration did not affect the Kiss1 mRNA levels of the AVPV in the ovariectomized or E2-treated rats. Conversely, DHT administration reduced the Kiss1 mRNA levels of the posterior hypothalamic block (the arcuate nucleus, ARC) in the ovariectomized rats. Although the Kiss1 mRNA levels of the posterior hypothalamic block (ARC) were decreased in the E2-treated rats, DHT administration did not affect the Kiss1 mRNA levels of the ARC in these rats. Serum luteinizing hormone levels of these groups exhibited similar patterns to the Kiss1 mRNA levels of the ARC. These results showed that DHT affects the production of hypothalamic reproductive and appetite regulatory factors, and that these effects of DHT differ according to the estrogen milieu.
Journal Title
Gynecological Endocrinology
ISSN
09513590
14730766
NCID
AA10839977
Publisher
Taylor & Francis
Volume
34
Issue
1
Start Page
73
End Page
77
Published Date
2017-06-11
Remark
This is an Accepted Manuscript of an article published by Taylor & Francis in Gynecological Endocrinology on 11/06/2017, available online: http://www.tandfonline.com/10.1080/09513590.2017.1337096.
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DOI (Published Version)
URL ( Publisher's Version )
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language
eng
TextVersion
Author
departments
University Hospital
Medical Sciences