ID 112464
Author
Seki, Ryohei National Institute of Genetics|Tohoku University
Li, Cai Chinese Academy of Sciences|BGI-Shenzhen|University of Copenhagen
Fang, Qi Chinese Academy of Sciences|BGI-Shenzhen
Egawa, Shiro Tohoku University
Hu, Jiang Chinese Academy of Sciences
Xu, Luohao Chinese Academy of Sciences
Pan, Hailin Chinese Academy of Sciences|BGI-Shenzhen
Kondo, Mao Tohoku University
Sato, Tomohiko Tohoku University
Matsubara, Haruka Tohoku University
Kamiyama, Namiko Tohoku University
Kitajima, Keiichi Tohoku University
Saito, Daisuke Tohoku University
Liu, Yang Chinese Academy of Sciences
Gilbert, M. Thomas P. University of Copenhagen|Norwegian University of Science and Technology
Zhou, Qi University of California
Xu, Xing Chinese Academy of Sciences
Shiroishi, Toshihiko National Institute of Genetics
Irie, Naoki University of Tokyo
Tamura, Koji Tohoku University
Zhang, Guojie Chinese Academy of Sciences|BGI-Shenzhen|University of Copenhagen
Content Type
Journal Article
Description
Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers. By analysing 48 bird genomes, we identified millions of avian-specific highly conserved elements (ASHCEs) that predominantly (>99%) reside in non-coding regions. Many ASHCEs show differential histone modifications that may participate in regulation of limb development. Comparative embryonic gene expression analyses across tetrapod species suggest ASHCE-associated genes have unique roles in developing avian limbs. In particular, we demonstrate how the ASHCE driven avian-specific expression of gene Sim1 driven by ASHCE may be associated with the evolution and development of flight feathers. Together, these findings demonstrate regulatory roles of ASHCEs in the creation of avian-specific traits, and further highlight the importance of cis-regulatory rewiring during macroevolutionary changes.
Journal Title
Nature Communications
ISSN
20411723
NCID
AA12645905
Publisher
Springer Nature
Volume
8
Start Page
14229
Published Date
2017-02-06
Remark
Supplementary Information : ncomms_8_14229_s1.pdf
Peer Review File : ncomms_8_14229_s3.pdf
DataSet 1 : ncomms_8_14229_s2.xlsx
Rights
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Institute of Advanced Medical Sciences