ID 112467
Author
Clark, Lars E. Harvard Medical School
Mahmutovic, Selma Harvard Medical School
Raymond, Donald D. Harvard Medical School
Dilanyan, Taleen Harvard Medical School
Manning, John T. University of Texas Medical Branch at Galveston
Shankar, Sundaresh Harvard Medical School
Levis, Silvana C. Instituto Nacional de Enfermedades Virales Humanas
Briggiler, Ana M. Instituto Nacional de Enfermedades Virales Humanas
Enria, Delia A. Instituto Nacional de Enfermedades Virales Humanas
Wucherpfennig, Kai W. Harvard Medical School|Dana-Farber Cancer Institute
Paessler, Slobodan University of Texas Medical Branch at Galveston
Abraham, Jonathan Harvard Medical School|Brigham and Women’s Hospital
Content Type
Journal Article
Description
While five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds transferrin receptor 1 (TfR1) using a surface that substantially varies in sequence among the viruses. As such, receptor-mimicking antibodies described to date are type-specific and lack the usual breadth associated with this mode of neutralization. Here we isolate, from the blood of a recipient of the live attenuated JUNV vaccine, two antibodies that cross-neutralize Machupo virus with varying efficiency. Structures of GP1–Fab complexes explain the basis for efficient cross-neutralization, which involves avoiding receptor mimicry and targeting a conserved epitope within the receptor-binding site (RBS). The viral RBS, despite its extensive sequence diversity, is therefore a target for cross-reactive antibodies with activity against New World arenaviruses of public health concern.
Journal Title
Nature Communications
ISSN
20411723
NCID
AA12645905
Publisher
Springer Nature
Volume
9
Start Page
1884
Published Date
2018-05-14
Remark
Supplementary Information : ncomms_9_1884_s1.pdf
Rights
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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DOI (Published Version)
URL ( Publisher's Version )
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language
eng
TextVersion
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departments
Medical Sciences