ID 112812
Title Alternative
Alkannin inhibits CCL3 and CCL5 production
Author
Shindo, Satoru Tokushima University
Ohta, Yoshihiro The University of Tokyo
Keywords
alkannin
CCL3
CCL5
NF‐κB
periodontal ligament cells
Content Type
Journal Article
Description
Alkannin, which is found in Alkanna tinctoria, a member of the borage family, is used as a food coloring. Alkannin has recently been reported to have certain biological functions, such as anti-microbial and anti-oxidant effects. It is known that CC chemokine receptor (CCR) 5-positive leukocytes contribute to alveolar bone resorption in periodontal lesions. The aim of this study was to examine whether alkannin inhibits the production of CC chemokine ligand (CCL) 3 and CCL5, which are CCR5 ligands, in human periodontal ligament cells (HPDLC). Interleukin (IL)-1β induced CCL3 and CCL5 production in HPDLC. Alkannin inhibited IL-1β-mediated CCL3 and CCL5 production in HPDLC in a dose-dependent manner. Moreover, we revealed that alkannin suppressed inhibitor of kappa B-α degradation in IL-1β-stimulated HPDLC. In addition, a nuclear factor (NF)-κB inhibitor significantly inhibited CCL3 and CCL5 production in IL-1β-stimulated HPDLC. These results demonstrate that alkannin inhibits CCR5 ligand production in IL-1β-stimulated HPDLC by attenuating the NF-κB signaling pathway.
Journal Title
Cell Biology International
ISSN
10656995
10958355
NCID
AA10882014
AA11544414
Publisher
International Federation for Cell Biology|Wiley
Volume
40
Issue
12
Start Page
1380
End Page
1385
Published Date
2016-10-24
Remark
This is the peer reviewed version of the following article: Hosokawa, Y. , Hosokawa, I. , Shindo, S. , Ohta, Y. , Ozaki, K. and Matsuo, T. (2016), Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells. Cell Biol Int, 40: 1380-1385, which has been published in final form at https://doi.org/10.1002/cbin.10692.
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Rights
© 2016 International Federation for Cell Biology
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Oral Sciences