ID 112816
Title Alternative
Gomisin N inhibits inflammatory cytokine production.
Author
Shindo, Satoru Tokushima University
Keywords
gomisin N
inflammatory cytokine
MAPKs
periodontal ligament cells
Content Type
Journal Article
Description
Gomisin N, which is a lignan isolated from Schisandra chinensis, has some pharmacological effects. However, the anti-inflammatory effects of gomisin N on periodontal disease are uncertain. The aim of this study was to examine the effect of gomisin N on inflammatory mediator production in tumor necrosis factor (TNF)-α-stimulated human periodontal ligament cells (HPDLC). Gomisin N inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 2, and CCL20 production in TNF-α-stimulated HPDLC in a dose-dependent manner. Moreover, we revealed that gomisin N could suppress extracellular signal-regulated kinase (ERK) and c-Jun N terminal kinase (JNK) phosphorylation in TNF-α-stimulated HPDLC though protein kinase B (Akt) phosphorylation was not suppressed by gomisin N treatment. In summary, gomisin N might exert antiinflammatory effects by attenuating cytokine production in periodontal ligament cells via inhibiting the TNF-α-stimulated ERK and JNK pathways activation.
Journal Title
Inflammation
ISSN
03603997
15732576
NCID
AA00673765
AA12117940
Publisher
Springer
Volume
40
Issue
2
Start Page
360
End Page
365
Published Date
2016-11-28
Remark
This is a post-peer-review, pre-copyedit version of an article published in Inflammation.
The final authenticated version is available online at: https://doi.org/10.1007/s10753-016-0482-4
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Oral Sciences